Journal article
Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin
FX Jiang, LC Harrison
Stem Cells and Development | MARY ANN LIEBERT, INC | Published : 2017
Abstract
Bone morphogenetic protein (BMP) signaling plays critical roles on the development of a large array of embryonic organs and promotes the in vitro formation of pancreatic cystoid colonies containing insulin-producing cells. However, this signaling and its underlying mechanism on in vivo development of prenatal pancreas have not been clearly understood. To address these questions, we analyzed, with a variety of techniques, the prenatal mouse pancreas after Pdx1 (the pancreas and duodenum homeobox factor 1 gene)-driving deletion of the BMP receptor type 1a gene (Bmpr1a). In this study, we report that the Pdx1-driving deletion of Bmpr1a transiently disrupted only the assembly of architectural st..
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Grants
Awarded by Juvenile Diabetes Research Foundation International
Funding Acknowledgements
The authors thank Dr. Illia Banakh, Dr. Kevin Li, and Mr. Gaetano Naselli for technical assistance; Prof. Pedro Herrera (University of Geneva, Geneva, Switzerland) for providing Pdx1-Cre mice; and Prof. B. Thorens (Universite De Lausanne, Lausanne, Switzerland) for providing antibody to Glut2. This study was supported by a Partnership Program Grant from the Juvenile Diabetes Research Foundation International and the National Health and Medical Research Council of Australia, by Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS (to L.C.H.), by grants from Juvenile Diabetes Research Foundation International (4-2006-1025), Telephon Perth Child Health Research Fund (TPCHRF), Diabetes Australia Research Trust, Diabetes Research Western Australia, and Medical Research Foundation of Royal Perth Hospital Grant (to F.-X.J.).